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Preheat oven to 350 degrees. Spray a loaf pan with non-stick cooking spray.
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Empty the contents of the mac and cheese into a medium sauce pan, and heat over medium heat. Stir in cooked, chopped bacon and jalapeños. Remove from heat and let sit while meatloaf is put together.
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In a medium bowl combine turkey, beef, stuffing mix, water, worcestershire sauce, onion and garlic powders, and salt and pepper. Do not over mix or meat will become tough. Using 3/4 of the meat mixture, form it into the loaf pan, leaving a boat in the center where the mac and cheese will go.
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Pour the mac and cheese (however much fits, you'll have extra to enjoy as a side) into the hallowed out boat of the meatloaf. Top with the remaining 1/4 of the meat mixture. Bake at 350 degrees for 50 minutes. Combine the sauce ingredients and set aside. After 50 minutes, remove from the oven, and flip the meatloaf onto a sheet pan. Pour the BBQ mixture over the top, and bake for an additional 10-15 minutes or until fully cooked through.
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Slice, serve, and enjoy! Can be served with remaining jalapeno bacon mac and cheese and your favorite veggies!